31P magnetic resonance spectroscopy of chronic cerebral infarction in rats
- 1 July 1989
- journal article
- Published by Wiley in NMR in Biomedicine
- Vol. 2 (2), 83-86
- https://doi.org/10.1002/nbm.1940020208
Abstract
The chronological changes in the pattern of 31P magnetic resonance spectroscopy (MRS) associated with cerebral infarction were studied in rats. 31P MRS of chronic infarction (1 month after induction of infarction) clearly showed a pattern distinct from that of normal brain. In chronic infarction, the relative phosphomonoester (PME) level was found to be significantly higher and relative phosphocreatine (PCr) level significantly lower compared to normal brain. The intracellular pH and the relative inorganic phosphate (Pi) level did not show any significant differences. Histological examination indicated that the 31P MRS pattern of chronic infarction reflects gliosis.Keywords
This publication has 9 references indexed in Scilit:
- Simultaneous 31P- and 1H-Nuclear Magnetic Resonance Studies of Hypoxia and Ischemia in the Cat BrainJournal of Cerebral Blood Flow & Metabolism, 1987
- Acute Cerebral Ischaemia: Concurrent Changes in Cerebral Blood Flow, Energy Metabolites, pH, and Lactate Measured with Hydrogen Clearance and 31P and 1H Nuclear Magnetic Resonance Spectroscopy. I. MethodologyJournal of Cerebral Blood Flow & Metabolism, 1987
- Chronic adult cerebral infarction studied by phosphorus NMR spectroscopy.Radiology, 1986
- A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction.Stroke, 1986
- Chemical characterization of a prominent phosphomonoester resonance from mammalian brain. 31P and 1H NMR analysis at 4.7 and 14.1 teslaJournal of Magnetic Resonance (1969), 1986
- Application ofin vivo NMR spectroscopy to cancerMagnetic Resonance in Medicine, 1984
- In vivo measurement of energy metabolism and the concomitant monitoring of electroencephalogram in experimental cerebral ischemiaBrain Research, 1984
- An efficient decoupler coil design which reduces heating in conductive samples in superconducting spectrometersJournal of Magnetic Resonance (1969), 1979