Effect of a human serum thymic factor on hydrocortisone‐treated thymocytes
- 1 December 1977
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 7 (12), 836-840
- https://doi.org/10.1002/eji.1830071203
Abstract
A human serum thymic factor (SF) stimulated cyclic adenosine-3′,5′-mono-phosphate (cAMP) synthesis in normal mouse thymocytes. Such stimulation was no longer observed when thymocytes were depleted of hydrocortisone (HC)-sensitive cells. It was concluded that SF selectively stimulates cAMP in HC-sensitive cells. Furthermore, incubation of thymocytes with SF enlarged the population of HC-resistant thymocytes. These results suggest that SF might act on HC-sensitive thymocytes increasing their cellular cAMP level and inducing their transformation in HC-resistant cells.This publication has 17 references indexed in Scilit:
- Thymic factor in human sera demonstrable by a cyclic AMP assayNature, 1976
- LYMPHOCYTE DIFFERENTIATION FROM PRECURSOR CELLS IN VITRO*Annals of the New York Academy of Sciences, 1975
- ANTIGENIC AND FUNCTIONAL EVIDENCE FOR THE IN VITRO INDUCTIVE ACTIVITY OF THYMOPOIETIN (THYMIN) ON THYMOCYTE PRECURSORS*Annals of the New York Academy of Sciences, 1975
- ISOLATION, BIOCHEMICAL CHARACTERISTICS, AND BIOLOGICAL ACTIVITY OF A CIRCULATING THYMIC HORMONE IN THE MOUSE AND IN THE HUMANAnnals of the New York Academy of Sciences, 1975
- DIFFERENTIATION OF T CELLS INDUCED BY PREPARATIONS FROM THYMUS AND BY NONTHYMIC AGENTSThe Journal of Experimental Medicine, 1973
- The effect of prostaglandins on cyclic AMP production and cell proliferation in thymic lymphocytesBiochemical and Biophysical Research Communications, 1971
- Cyclic adenosine 3′,5′-monophosphate in human lymphocytes. Alterations after phytohemagglutinin stimulationJCI Insight, 1971
- Characteristics of the immunocompetent cells in the mouse thymus: Cell population changes during cortisone-induced atrophy and subsequent regenerationCellular Immunology, 1970
- Evidence for a small pool of immunocompetent cells in the mouse thymusExperimental Cell Research, 1969
- An adrenergic receptor mechanism for the control of cyclic 3′5′ adenosine monophosphate synthesis in tissuesBiochemical and Biophysical Research Communications, 1967