Methoxychlor as a Model for Environmental Estrogens
Open Access
- 1 January 1997
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Toxicology
- Vol. 27 (4), 367-379
- https://doi.org/10.3109/10408449709089899
Abstract
Estrogens can have a variety of physiological effects, especially on the reproductive system. Chemicals with estrogenic activity that are present in the environment may thus be considered potentially hazardous to development and/or reproduction. Methoxychlor is one such chemical, a chlorinated hydrocarbon pesticide with proestrogenic activity. Metabolism of the chemical eitherin vivo or using liver microsomes produces 2,2-bis(p-hydroxyphenyl)- 1,1,1-trichloroethane (HPTE), the active estrogenic form, and the delineation of this mechanism is reviewed herein. When administeredin vivo, methoxychlor has adverse effects on fertility, early pregnancy, andin utero development in females as well as adverse effects on adult males such as altered social behavior following prenatal exposure to methoxychlor. Effects of methoxychlor on the female have been studied extensively, whereas reports on the chemical's effects on males are less common. From the studies reviewed here, the reproductive toxicity of methoxychlor is evident, but the significance of this toxicity with respect to human health remains to be determined.Keywords
This publication has 63 references indexed in Scilit:
- Methoxychlor Regulates Rat Uterine Estrogen-Induced ProteinToxicology and Applied Pharmacology, 1995
- Response of adult murine uterine epithelium to 50% methoxychlorReproductive Toxicology, 1994
- Passage of methoxychlor in milk and reproductive organs of nursing female mice; 1. Light and scanning electron microscopic observationsReproductive Toxicology, 1992
- Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnanciesReproductive Toxicology, 1992
- Ultrastructure of vagina and uterus in young mice after methoxychlor exposureReproductive Toxicology, 1991
- Comparative sublethal ovarian pathology of some pesticides in the teleost,Puntius conchonius HamiltonBulletin of Environmental Contamination and Toxicology, 1988
- Methoxychlor affects the decidual cell response of the uterus but not other progestational parameters in female rats*1, *2Toxicology and Applied Pharmacology, 1987
- A novel method for demonstrating proestrogens. Metabolism of methoxychlor and o, p'DDT by liver microsomes in the presence of uteri and effects on intracellular distribution of estrogen receptorsLife Sciences, 1979
- Species differences in egg transport in response to exogenous estrogenThe Anatomical Record, 1967
- Synergism among oral carcinogens: I. Results of the simultaneous feeding of four tumorigens to ratsToxicology and Applied Pharmacology, 1965