The Effectiveness of Ovarian and Hypophysial Grafts in the Production of Mammary Carcinoma in Mice

Abstract

Ovarian transplants caused a high rate of mammary cancer in castrated mice, whereas normal were about equally susceptible to ant. pituitary transplants or to a combination of ant. pit. and ovary. Results were less marked in low tumor strains. A parallelism existed between the body wt. and the hormone effectiveness. Ovariectomy inhibited the cancerigenic ant. pituitary action. Mammary cancer rate in castrates was marked after a single transplant which produced mammary stimulating hormones. In all transplants, cancer cells developed only after 6-12 mos. Mammary cancer due to ovary or ant. pituitary extracts is inhibited by genetic constitution, insufficient milk factor or poor survival of the grafts.