Indirect Radiation Effects and Diffusible Factors in Irradiated Tissues (Stromatex)

Abstract

The interplay of irradiated and normal tissues and the role of diffusible substances in radiation-induced inflammatory reactions are discussed. The time at which the maximum yield of biologically active material is obtained from irradiated skin was established in experiments with vital dyes injected into the animals at varying intervals after irradiation. The technique of perfusion of rabbits'' skin is described and the results of tests on mitotic inhibition in tissue cultures of chick and mouse fibroblasts by perfusates from irradiated skin (stromtex) and normal skin of the same animals are given.