THE EFFECT OF HISTAMINE UPON THE SECRETION OF GASTRIC PEPSIN

Abstract

Studies of the response of the pepsin secreting glands to histamine stimulation were made in 7 gastric pouch dogs of the Pavlov and Heidenhain type. With increased volume of secretion in response to histamine stimulation, there was a relative decrease in pepsin concentration, indicating that the histamine had not stimulated pepsin secretion. A parallelism between pepsin and neutral chloride concentration in the gastric juice was also observed.