Analysis of Fibrinolysis by the Use of Epsilon-Aminocaproic Acid: Preliminary Report

Abstract

From the foregoing analysis of the inhibitory action of ε-aminocaproic acid in the fibrinolytic process, it is evident that the process involves two reaction phases, fibrinolysis and metafibrinolysis. Fibrinolysopeptide and metafibrin are split off from fibrin in fibrinolysis. The former is a peptide with N-terminal glycine, while the latter is a monochloracetic acid-soluble metaprotein having both aspartic acid and tyrosine as N-terminal amino acids.