Clinical Assessment Of Disease Activity In Rheumatoid Arthritis

Abstract

A new experimental design was developed to study the value of clinical parameters of disease activity in patients with rheumatoid arthritis. Ten patients with classical rheumatoid arthritis were examined by 5 senior doctors in a department of medical rheumatology. In spite of an attempt to make the clinical examination as uniform as possible, the inter-observer variation among the doctors was greater than the variation among the patients for the following parameters: joint pain at rest, joint tenderness and joint swelling. An acceptable inter-observer variation in relation to patient variation was found for these parameters: a combined registration of joint pain at rest or on movement, morning stiffness duration, grip strength, subjective well-being indicated on a visual analog scale, fingertip-palm distance and maximum flexion-extension in elbows, wrists and knees. The variation from morning to afternoon and from day to day was negligible. Registration of elaborated articular scores is useless in the daily routine in rheumatological departments when different doctors examine the patients.