A LIGHT AND ELECTRON MICROSCOPIC HISTOCHEMICAL STUDY ON THE MECHANISM OF DFP‐INDUCED ACUTE AND SUBACUTE MYOPATHY
- 1 September 1981
- journal article
- research article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 7 (5), 399-410
- https://doi.org/10.1111/j.1365-2990.1981.tb00241.x
Abstract
Histochemical changes occuring in association with the development of acute and subacute myopathy were studied in the rat diaphragm 30 min to 48 h after a single i.p. injection of 1.82 mg/kg of the irreversible cholinesterase inhibitor organophosphate [insecticide] DFP. In addition to a considerable inhibition of the AChE [acetylcholinesterase] activity of the motor end-plates, accumulation of ionic Ca2+ and increased neutral protease activity in the subjunctional sarcoplasm were demonstrated. A temporal and causal relationship was established between the histochemical changes and the development of the ultrastructural signs of myopathy.This publication has 31 references indexed in Scilit:
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