The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA
Open Access
- 1 October 2003
- journal article
- research article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 5 (10), 695-707
- https://doi.org/10.1046/j.1462-5822.2003.00311.x
Abstract
Among bacterial protein toxins, the cytolethal distending toxins (CDTs) are unique in their ability to activate the DNA damage checkpoint responses, causing cell cycle arrest or apoptosis in intoxica...Keywords
This publication has 49 references indexed in Scilit:
- ATM Phosphorylates Histone H2AX in Response to DNA Double-strand BreaksJournal of Biological Chemistry, 2001
- The cytolethal distending toxins induce DNA damage and cell cycle arrestToxicon, 2001
- Rho signals to cell growth and apoptosisCancer Letters, 2001
- The Haemophilus ducreyi Cytolethal Distending Toxin Induces Cell Cycle Arrest and Apoptosis via the DNA Damage Checkpoint PathwaysJournal of Biological Chemistry, 2001
- Ras and Rho GTPasesCell, 2000
- DNase I homologous residues in CdtB are critical for cytolethal distending toxin‐mediated cell cycle arrestMolecular Microbiology, 2000
- Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPasesJournal of Biological Chemistry, 1999
- The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phaseJournal of Clinical Investigation, 1999
- Poly ADP-ribosylation: A DNA break signal mechanismMolecular and Cellular Biochemistry, 1999
- Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosisOncogene, 1997