THE EFFECT OF BENZEDRINE (β-PHENYLISOPROPYLAMINE SULPHATE) AND PAREDRINE (ρ-HYDROXY -α-METHYL-PHENYLETHYLAMINE HYDROBROMIDE) ON THE CIRCULATION, METABOLISM AND RESPIRATION IN NORMAL MAN 1

Abstract

Benzedrine and paredrine in doses of 20 mg. or more caused a marked rise in systolic and diastolic blood pressures in normal man. The cardiac output, pulmonary circulation time, vital capacity, basal metabolic rate, and respiratory dynamics were not changed. The effects of adrenalin in man were quite different from those of benzedrine and paredrine. They consisted in a slight rise in systolic pressure, no change or fall in diastolic pressure, marked increase in cardiac output, and shortening of the circulation time. Benzedrine in doses ordinarily used clinically, i.e., 5 to 10 mg., has no significant effect on the cardiovascular dynamics.