A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.
- 1 May 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (9), 3055-3057
- https://doi.org/10.1073/pnas.82.9.3055
Abstract
A mechanism is proposed for a molecular switch that can store information indefinitely, despite the complete turnover of the molecules that make up the switch. The design of the switch is based on known types of biochemical reactions. Central to the mechanism is a kinase that is activated by phosphorylation and is capable of intermolecular autophosphorylation. Such a kinase and an associated phosphatase form a bistable chemical switch that can be turned on by an external stimulus and that is not reset by protein turnover.Keywords
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