The Estimation from Individual Records of the Relationship Between Dose and Quantal Response

Abstract

In certain expts. it is not possible to administer doses at fixed levels to the subjects, although it is possible later to measure the dose each actually receives. Probit methods are given to make possible the regression analysis of the relationship between dose and response. An example is given in which dose is expressed in terms of 2 measurements and a probit plane is estimated. The validity of x 2 in testing goodness of fit is doubted, since the dose groups are necessarily small. Various adjustments in the calculation of x 2 are considered in some detail.