Synthesis and Confirmation of the Absolute Stereochemistry of the (−)-Aflastatin A C9−C27 Degradation Polyol
- 21 June 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (15), 3335-3338
- https://doi.org/10.1021/ol051225n
Abstract
The C8−C18 ethyl ketone and C19−C28 aldehyde aflastatin A fragments were synthesized and coupled using a diastereoselective anti aldol reaction. This adduct was successfully converted into the C9−C27 polyol degradation product of (−)-aflastatin A to confirm the relative and absolute stereochemistry of this region of the natural product.Keywords
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