Structural model for the CuB site of dopamine β-hydroxylase and peptidylglycine α-hydroxylating monooxygenase: crystal structure of a copper(ii) complex showing N3OS coordination and axial sulfur ligation

Abstract

A copper(II) complex [Cu(L)(phen)](ClO₄) (HL, NSO-donor Schiff base ligand) with a Cu^IIN₃OS geometry showing axial sulfur ligation is a structural model for the Cu_B site of DβH and PHM, and the complex is catalytically active in the oxidation of ascorbic acid by dioxygen mediated by a copper(I) species.