The solubility of 17 β-oestradiol in aqueous polyethylene glycol 400
- 1 December 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (12), 799-802
- https://doi.org/10.1111/j.2042-7158.1984.tb04880.x
Abstract
The solubility of 17 β-oestradiol (E2) in aqueous solutions of polyethylene glycol (PEG) 400 has been measured at 35 °C. Up to 80% w/w PEG the solubility data conform to a log linear equation In S = In Sw + fø where S is the E2 concentration in the water/cosolvent mixture, Sw is E2 solubility in water, f is the weight fraction of PEG 400 and ø is a parameter representing the solubilizing power of the cosolvent for the drug. Above 80% PEG the relationship becomes less convincing, with significant deviation from anticipated values. Reasons for these aberrations are discussed. It is suggested that conformational changes may be induced in the PEG by the addition of small quantities of water. Deviations noted for the melting point, viscosity and density data of PEG 400-water solutions may also confirm this suggestion.This publication has 10 references indexed in Scilit:
- Extended Hildebrand Solubility Approach and the Log Linear Solubility EquationJournal of Pharmaceutical Sciences, 1982
- The interaction of phospholipid membranes with poly(ethylene glycol). Vesicle aggregation and lipid exchangeBiochimica et Biophysica Acta (BBA) - Biomembranes, 1982
- Polyethylene glycols as solvents in implantable osmotic pumpsJournal of Pharmaceutical Sciences, 1980
- Determination of Aqueous Solubility and pKa Values of EstrogensJournal of Pharmaceutical Sciences, 1977
- Aqueous solubility of steroid hormones: an explanation for the discrepancy in the published dataJournal of Pharmacy and Pharmacology, 1975
- Solubility of Nonelectrolytes in Polar SolventsJournal of Pharmaceutical Sciences, 1972
- Interactions of estradiol-17β with amino acidsJournal of Steroid Biochemistry, 1971
- Molecular Vibrations and Structure of High Polymers. III. Polarized Infrared Spectra, Normal Vibrations, and Helical Conformation of Polyethylene GlycolThe Journal of Chemical Physics, 1962
- The morphology and internal structure of poly(ethylene oxide) spherulitesJournal of Polymer Science, 1962
- Molecular Vibrations and Structures of High Polymers. I. General Method of Normal Coordinate Treatment by Internal Coordinates and Infrared Frequencies and Conformations of (—CH2—)n, (—CH2–O—)n, and (—CH2–O–CH2—)nThe Journal of Chemical Physics, 1961