A NOTE ON THE EFFECT OF DITHIOTHREITOL (DTT) ON THE DEPOLARIZATION OF ISOLATED SYMPATHETIC GANGLIA BY CARBACHOL AND BROMO‐ACETYLCHOLINE
Open Access
- 1 January 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 56 (1), 128-130
- https://doi.org/10.1111/j.1476-5381.1976.tb06968.x
Abstract
The S-S reducing agent, dithiothreitol (DTT) altered the properties of nicotinic receptors in rat superior cervical ganglia such that (i) carbachol became less active as a depolarizing agent and (ii) bromo-acetylcholine produced an irreversible depolarization. The latter was temporarily annulled by hexamethonium (which retained antagonist properties), but returned when hexamethonium was removed. It is concluded that ganglionic nicotinic receptors might be quite similar to those for mono-quaternary agonists in leech dorsal muscle.Keywords
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