Failure of Actinomycin D to Inhibit Antitoxin Production to a Challenging Injection of Antigen.

Abstract

Summary Daily injections of Actinomycin D, which were sufficiently high to produce marked weight losses and other toxic manifestations, failed to eliminate antitoxin production to a challenging injection of tetanus toxoid. Since DNA-dependent RNA synthesis was presumably inhibited, the data support the existence of a persisting inactivated mRNA, in a form which is activated by the reinjection of antigen.