Patterns of local-regional recurrence and results In Stages I and II breast cancer treated by irradiation following limited surgery An update

Abstract

A total of 146 women with stage I and stage II breast cancer received radical radiotherapy after having excisional biopsy (lumpectomy) at Massachusetts General Hospital [Boston, Massachusetts, USA] between 1956-1978. They were grouped according to age as follows: those younger than 49 yr and those older than 50 yr. The 5-yr survival rates were 93% and 73% for patients with stage I and stage II cancer, respectively; the corresponding 5-yr relapse survival rates were 75% and 56%, respectively. The local recurrence rate was 8% in patients with stage I disease and 17% in those with stage II disease. Survival was not significantly affected by patients'' age, by the presence or absence of blood vessel or lymphatic involvement or by the addition of adjuvant chemotherapy. No major complications occurred. Modification in radiation dose and technique resulted in improved overall survival and local control. Limited surgery followed by radical radiation therapy offers a therapeutically effective, cosmetically acceptable alternative to radical surgery for early stage breast cancer.