Detroit-6 Strain of Human Epithelial-Like Cells: Virus Susceptibilities

Abstract

A new strain of human epithelial-like cells, the Detroit-6 strain, was derived from the bone marrow of a patient with carcinoma of the lung. Since its isolation this strain was maintained for nearly a year through continuous sub-culture on glass without discernible change in morphologic characteristics or growth pattern. Preliminary studies of the susceptibility of Detroit-6 cells of a selected group of viruses indicated that whereas influenza viruses could not be prepagated, and did not cause cellular degeneration, representative strains of poliomyelitis viruses types 1, 2 and 3, a Coxsackie virus, type B-1, and a recently isolated strain of herpes simplex virus, multiplied within these cells and produced cytopathogenic effects.