Technique Technique Figure 3 Figure 4 Figure 5 Figure 6 Technique Figure 7 Figure 8 Figure 9 Figure 10 Metastatic Melanoma Fig. 11.—Before perfusion. Fig. 12.—Two years after perfusion. Case 1. —A 77-year-old white man. In 1956 malignant melanoma removed from left foot, followed by groin dissection May, 1957: Appearance of multiple dermal metastases. June, 1957: Isolated perfusion with 120 mg. phenylalanine mustard (PAM) through common femoral artery. Fig. 13.—Original lesion. Fig. 14.—Metastasis, six weeks after perfusion. Fig. 15.—Metastasis, eight weeks after perfusion. Melanoma Figure 16 Case 2. —1947: Small mole (malignant melanoma) removed from right medical lower leg. 1958: Local recurrence followed by multiple excisions. Treated with TSPA intra-arterially without improvement (Fig. 16, A). December, 1958: Common femoral artery perfusion with 130 mg. PAM (1.8 mg. per kilogram of body weight). January, 1959: Many lesions disappeared (Fig. 16, B). Figure 17 Case 3. —1957: Malignant melanoma with extensive metastases