Intracranial Drug Implants: An Autoradiographic Analysis of Diffusion
- 12 December 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3911), 1410-1412
- https://doi.org/10.1126/science.166.3911.1410
Abstract
Labeled crystalline atropine, administered to the hypothlalamus of rats, remainted strictly localized in a sphere, 1.0 to 1.8 millimeters in diameter, ditring the first 3 minutes. A similar distribution obtained after 1 hour. At intermediate times, slightly elevated radioactivity, reflecting concentrations 2,000 to 10,000 times below behaviorally effective doses, was observed several millimeters from the implantation site.Keywords
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