Anti-B Lymphocytotoxins in Renal-Allograft Rejection
- 5 August 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 295 (6), 305-309
- https://doi.org/10.1056/nejm197608052950603
Abstract
To determine the possible role of the B lymphocyte alloantigen system in renal-transplant rejection, we examined serum specimens from 81 allograft recipients for cytotoxic activity against a panel of normal B lymphocytes. Specimens from 22 of 25 recipients undergoing allograft rejection demonstrated strong B-lymphocyte cytotoxicity whereas only 13 of 56 recipients with normal allograft function showed similar B lymphocyte cytotoxicity (P<0.0001). In the serum samples of recipients with graft rejection who were followed sequentially, B-lymphocyte cytotoxicity preceded or was concurrent with the onset of functional impairment. The results show that anti-B-lymphocyte antibodies are associated with rejection, but it is quite possible that they are the products of rejection rather than the cause. (N Engl J Med 295:305–309, 1976)This publication has 19 references indexed in Scilit:
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