THE EFFECT OF BILATERAL OVARIECTOMY IN CATS UPON SENSITIVITY TO INSULIN

Abstract

Bilateral ovariectomy in 4 cats caused an immediate increase in sensi tivity to insulin and was followed by a marked increase in weight. There was a gradual recovery of resistance to insulin to such an extent that the sensitivity was subsequently diminished in comparison with that of the intact animal. Blood sugar levels and the general reaction to insulin did not coincide from time to time. This would suggest that insulin shock and hypoglycemia are separate and distinct manifestations resulting from the injection of insulin. There seems to be an exaggeration of their independence following the recovery of the animal from the immediate effects of ovariectomy.