Increased Susceptibility of Secretor Factor Gene Fut2 -Null Mice to Experimental Vaginal Candidiasis
- 1 July 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (7), 4279-81
- https://doi.org/10.1128/iai.72.7.4279-4281.2004
Abstract
Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.Keywords
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