PANCREATIC-POLYPEPTIDE AND VAGAL-STIMULATION OF GASTRIC AND PANCREATIC-SECRETION IN DOGS

Abstract

In 4 dogs provided with pancreatic, gastric and esophageal fistulae, the effects of bovine pancreatic polypeptide (BPP) infused at a physiological dose level (240 pmol/kg per h) on gastric and pancreatic responses to sham-feeding were studied. The maximal gastric and pancreatic secretion was produced by pentagastrin and secretin and OP-CCK [octapeptide of cholecystokinin] infusion, respectively, with or without addition of BPP. Exogenous BPP did not change gastric acid and pepsin outputs stimulated by pentagastrin or sham-feeding, but significantly inhibited basal and maximally stimulated pancreatic protein secretion. The peak pancreatic protein, but not bicarbonate response to sham-feeding, was reduced .apprx. 31% by BPP. This reduction by BPP amounted to .apprx. 57% when the pancreas was stimulated maximally by OP-CCK. PP released by cephalic-vagal excitation does not affect gastric secretion, but inhibits pancreatic protein secretion and thus might contribute to the lower pancreatic response to sham-feeding as compared with that produced by exogenous stimulants such as secretin and OP-CCK.