Sustained reductions in oxipurinol renal clearance during a restricted diet
- 1 June 1987
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 41 (6), 616-621
- https://doi.org/10.1038/clpt.1987.84
Abstract
The renal clearance of oxipurinol, the major metabolite of allopurinol, was studied in six healthy subjects during normal and restricted (low protein and low calorie) diets. A 600 mg oral dose of allopurinol was administered after 7 days of a normal diet (100 mg protein/day) and again after 2 and 4 weeks of a restricted diet (19 gm protein/day). The renal clearance of oxipurinol was reduced from 19.6 .+-. 1.5 ml/min during the normal diet to 10.9 .+-. 0.8 and 12.0 .+-. 0.9 ml/min (both P < 0.001) during the restricted diet at 2 and 4 weeks, respectively. These changes in oxipurinol renal clearance paralleled changes in uric acid renal clearance. Furthermore, the plasma oxipurinol half-life was increased from 27.0 .+-. 1.7 hours during the normal diet to 51.1 .+-. 4.3 and 45.7 .+-. 3.7 hours (both P < 0.001) during the restricted diet at 2 and 4 weeks, respectively. We conclude that dietary protein and calorie restriction cause a sustained reduction in the elimination of oxipurinol.This publication has 2 references indexed in Scilit:
- Severe allopurinol toxicityAmerican Journal Of Medicine, 1984
- Hormone-fuel interrelationships during fasting.JCI Insight, 1966