THE EFFICIENCY OF CLIOXANIDE AND RAFOXANIDE AGAINST FASCIOLA HEPATICA IN SHEEP BY DIFFERENT ROUTES OF ADMINISTRATION
- 1 November 1975
- journal article
- Published by Wiley in Australian Veterinary Journal
- Vol. 51 (11), 500-503
- https://doi.org/10.1111/j.1751-0813.1975.tb06899.x
Abstract
Groups of sheep were infected with 100 viable metacercariae of Fasciola hepatica. The efficiencies of clioxanide and rafoxanide were evaluated against infections aged 6 and 12 weeks, by using 3 dose rates of each compound by each of 3 routes of administration. Clioxanide, at 40 mg/kg, administered orally and intra-ruminally against 6-week-old liver fluke was 85 and 90% efficient respectively. At 80 mg/kg intra-abomasally its efficiency was 43%. Clioxanide at 20 mg/kg was 96% efficient against 12-week-old liver fluke when given orally or intra-ruminally and 82% efficient when given intra-abomasally. Because of its lower efficiency intra-abomasally, clioxanide may be unsatisfactory in a proportion of sheep, for use against immature liver fluke at a dose rate of 40 mg/kg. It may be expected to give a moderate to high efficiency against mature infections at 20 mg/kg.Keywords
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