THE EFFECT OF PYRIDOXINE ON THE URINARY EXCRETION OF A NEW FLUORESCENT SUBSTANCE

Abstract

A dose of 100 mg. of pyridoxine hydrochloride to normal and pellagrous patients is followed by a 4- to 10-fold increase in a bluish-purple fluorescence during the first 4-hr. period as compared to the preceding control period. The substance responsible for the increased fluorescence resembles F,1 (a fluorescent substance normally present) in its adsorption on permutit, elution with 25% KCl soln. and extraction from the eluate with isobutanol but differs from F1 in that it is extracted from only the untreated eluate.