The synaptic membrane D2‐protein in amniotic fluid from pregnancies with fetal neural tube defects
- 1 January 1981
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 1 (1), 3-6
- https://doi.org/10.1002/pd.1970010103
Abstract
The D2-protein is a neuronal membrane protein which has an immunochemically detectable soluble derivative in cerebrospinal fluid. We used rocket-on-line immunoelectrophoresis with an antiserum against rat synaptosomal membranes for demonstration of the human D2-protein in fetal cerebrospinal fluid and in amniotic fluids from pregnancies with fetal neural tube defects. D2 was neither found in normal amniotic fluids nor in cases of amniotic fluids from pregnancies with other malformations. Analysis of D2 in amniotic fluids may thus have a future role in the antenatal diagnosis of fetal neural tube defects.Keywords
This publication has 14 references indexed in Scilit:
- The nervous system specific protein D2 is involved in adhesion among neurites from cultured rat gangliaFEBS Letters, 1980
- Reactivity of amniotic fluid alpha-fetoprotein with concanavallin A in diagnosis of neural tube defects.BMJ, 1979
- AMNIOTIC-FLUID ACETYLCHOLINESTERASE AS A POSSIBLE DIAGNOSTIC TEST FOR NEURAL-TUBE DEFECTS IN EARLY PREGNANCYThe Lancet, 1979
- LOCALIZATION OF THE ANTIGENS D1, D2 AND D3 IN THE RAT BRAIN SYNAPTIC MEMBRANEJournal of Neurochemistry, 1976
- Clinical Immunology Report of the Committee on Clinical Immunology of the International Union of Immunological Societies (IUIS)Scandinavian Journal of Immunology, 1976
- Synaptic Plasma Mèmbrane Antigen D2 Measured in Human Cerebrospinal Fluid by Rocket‐Line Immunoelectrophoresis. Determination in Psychiatric and Neurological PatientsScandinavian Journal of Immunology, 1975
- Rat brain synaptic vesicles and synaptic plasma membranes compared by crossed immunoelectrophoresisFEBS Letters, 1975
- Brain specific synaptosomal membrane proteins demonstrated by crossed immunoelectrophoresisJournal of Neurochemistry, 1974
- Rocket‐Line Immunoelectroplioresis (76)Scandinavian Journal of Immunology, 1973