A NOVEL CELL TYPE CARRYING BOTH Th AND Tc/s MARKERS IN THE BLOOD OF CYCLOSPORINE-TREATED, ALLOGRAFTED RATS
- 1 June 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 39 (6), 624-628
- https://doi.org/10.1097/00007890-198506000-00010
Abstract
During treatment of heart-grafted rats with cyclosporine (CsA), an unusual large lymphocyte appears in the blood. These cells constitute up to 40% of the peripheral blood leukocyte population and carry both the T helper/DTH and T cytotoxic/suppressor differentiation antigens. They require both the allograft and CsA for their generation and are not recently thymus-derived. They gradually disappear after stopping CsA treatment, although the treated rats remain tolerant of the graft.This publication has 4 references indexed in Scilit:
- FUNCTION AND MIGRATION OF SUPPRESSOR LYMPHOCYTES FROM CYCLOSPORINE-TREATED HEART GRAFT RECIPIENTSTransplantation, 1983
- Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymusEuropean Journal of Immunology, 1982
- PATHOLOGICAL CHANGES DEVELOPING IN THE RAT DURING A 3-WEEK COURSE OF HIGH DOSAGE CYCLOSPORIN A AND THEIR REVERSAL FOLLOWING DRUG WITHDRAWALTransplantation, 1981
- CYCLOSPORIN A SPARES SELECTIVELY LYMPHOCYTES WITH DONOR-SPECIFIC SUPPRESSOR CHARACTERISTICSTransplantation, 1981