The Effect of Histamine Upon the Local Fixation of Antibodies in the Skin of the Guinea Pig

Abstract

The latent period of sensitization of passive cutaneous anaphylaxis of the guinea-pig is inversely proportional to the amount of antibody injected intravenously to sensitize the animal. The injection of very small doses of histamine intradermally, or the local treatment with mild irritants, can bring about preferentially the appearance of the reaction of passive cutaneous anaphylaxis at the treated site; small doses of histamine or other mild inflammatory agents are therefore able to bring about the local fixation of circulating antibody.