DDT Administered to Neonatal Rats Induces Persistent Estrus Syndrome
- 13 August 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 173 (3997), 642-643
- https://doi.org/10.1126/science.173.3997.642
Abstract
The o,p'-isomer of the insecticide DDT when injected into neonatal female rats significantly advanced puberty, induced persistent vaginal estrus after a period of normal estrous cycles, and caused the ovaries to develop follicular cysts and a reduced number of corpora lutea. The uterotropic response to administered estradiol was reduced, and the female pattern of mating behavior was slightly disturbed. Residues of DDT in ovarian, brain, and adipose tissues of the adult animals were the same in both treated and control groups.Keywords
This publication has 14 references indexed in Scilit:
- Degradation and Disappearance of ortho, para Isomer of Technical DDT in Living and Dead Avian TissuesScience, 1969
- Oestrogen Receptors in Androgen or Oestrogen Sterilized Female RatsNature, 1969
- Estrogenic action of DDT and its analogsToxicology and Applied Pharmacology, 1969
- PERSISTENT ESTRUSObstetrical & Gynecological Survey, 1969
- Estrogenic Activity of o , p ′-DDT in the Mammalian Uterus and Avian OviductScience, 1968
- Sexual Development altered by Non-steroidal OestrogensNature, 1968
- Feminine Behavior in Neonatally Castrated and Estrogen-Treated Male RatsScience, 1965
- The Upjohn Lecture of the Endocrine Society Sex Hormones, Brain Development and Brain Function12Endocrinology, 1964
- STUDIES ON MATING BEHAVIOUR IN THE ANDROGEN-STERILIZED FEMALE RAT IN RELATION TO THE HYPOTHALAMIC REGULATION OF SEXUAL BEHAVIOURJournal of Endocrinology, 1962
- EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT1Endocrinology, 1961