Inhibitors of photosystem II and the topology of the herbicide and QB binding polypeptide in the thylakoid membrane
- 1 January 1986
- journal article
- Published by Springer Nature in Photosynthesis Research
- Vol. 10 (3), 381-392
- https://doi.org/10.1007/bf00118304
Abstract
The folding through the thylakoid membrane of the D-1 herbicide binding polypeptide and of the homologous D-2 subunit of photosystem II is predicted from comparison of amino acid sequences and hydropathy index plots with the folding of the subunits L and M of a bacterial photosystem. As the functional amino acids involved in Q and Fe binding in the bacterial photosystem of R. viridis, as indicated by the X-ray structure, are conserved in the homologous D-1 and D-2 subunits of photosystem II, a detailed topology of the binding niche of QB and of herbicides on photosystem II is proposed. The model is supported by the observed amino acid changes in herbicide tolerant plants and algae. These changes are all in the binding domain on the matrix side of the D-1 polypeptide, and turn out to be of functional significance in the QB binding. New inhibitors of QB function are described. Their chemical structure, i.e. pyridones, quinolones, chromones and benzodiones, contains the features of the phenolic type herbicides. Their essential elements, π-charges at particular atoms, QSAR and steric requirements for optimal inhibitory potency are discussed and compared with the “classical” herbicides of the urea/triazine type.Keywords
This publication has 61 references indexed in Scilit:
- Simple and discrete isolation of an O2‐evolving PS II reaction center complex retaining Mn and the extrinsic 33 kDa proteinFEBS Letters, 1985
- The azido[14C]atrazine photoaffinity technique labels a 34‐kDa protein in Scenedesmus which functions on the oxidizing side of photosystem IIFEBS Letters, 1985
- The role of chloride in Photosystem IIBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1985
- Effect of trypsin on PS-II particles. Correlation between Hill-activity, Mn-abundance and peptide patternBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1985
- X-ray structure analysis of a membrane protein complexJournal of Molecular Biology, 1984
- Photoaffinity labeling of the azidoatrazine receptor site in reaction centers of Rhodopseudomonas sphaeroidesFEBS Letters, 1984
- Will the seven‐helix bundle be a common structure for integral membrane proteins?FEBS Letters, 1983
- Theoretical study of the binding site and mode of action for photosystem II herbicidesJournal of Theoretical Biology, 1981
- Electron‐dependent competition between plastoquinone and inhibitors for binding to photosystem IIFEBS Letters, 1981
- Photoaffinity labelling of the photosystem II herbicide binding proteinFEBS Letters, 1980