‐independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes
- 21 December 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (2), 517-522
- https://doi.org/10.1016/j.febslet.2004.12.020
Abstract
Apoptosis of rat cardiomyocytes induced by staurosporine is prevented by a stilbene derivative (DIDS), which is a known blocker of both Cl-/HCO3- exchangers and Cl− channels. To clarify its target, staurosporine-induced activation of caspase-3, DNA laddering and cell death were examined in cultured rat cardiomyocytes. Removal of ambient HCO3-, which minimizes the function of Cl-/HCO3- exchangers, failed to affect the preventive effect of DIDS on apoptosis. A carboxylate analog Cl− channel blocker, which does not block Cl-/HCO3- exchangers, also inhibited apoptotic events. Thus, rescue by DIDS of cardiomyocytes from apoptosis is mediated by blockage of Cl− channelsKeywords
This publication has 26 references indexed in Scilit:
- Activation of K+channels: an essential pathway in programmed cell deathAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2004
- Regulation of Intracellular pH Mediates Bax Activation in HeLa Cells Treated with Staurosporine or Tumor Necrosis Factor-αJournal of Biological Chemistry, 2002
- Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)The Journal of Physiology, 2001
- Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3Journal of Molecular and Cellular Cardiology, 1998
- Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.Journal of Clinical Investigation, 1997
- Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.Journal of Clinical Investigation, 1997
- Na+-dependent and -independent Cl−/HCO3 − exchange mediate cellular HCO3 − transport in cultured human intrahepatic bile duct cellsHepatology, 1997
- Apoptosis in Human Acute Myocardial InfarctionCirculation, 1997
- Conservation of an AE3 Cl − /HCO 3 − Exchanger Cardiac-Specific Exon and Promoter Region and AE3 mRNA Expression Patterns in Murine and Human HeartsCirculation Research, 1995
- Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.Circulation Research, 1994