Molecular Characterization of theEscherichia coliFimH Adhesin

Abstract
Bacterial adherence mediated by fimbriae is an essential prerequisite for colonization of the urinary tract. Uropathogenic Escherichia coli express a number of different adhesive organelles, including P, type 1, S, and F1C fimbriae [1]. Type 1, or mannose-sensitive, fimbriae are produced by >80% of all uropathogenic E. coli. It is now well established that the expression of type 1 fimbriae by E. coli is a virulence factor for pathogenesis of the urinary tract [2, 3]