Moxalactam (LY127935) in treatment of meningitis due to gram-negative bacilli
- 1 February 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 19 (2), 218-221
- https://doi.org/10.1128/aac.19.2.218
Abstract
Moxalactam (LY127935; 6059S), a new broad-spectrum beta-lactam antibiotic, was used successfully with an aminoglycoside in a patient with Serratia marcescens meningitis complicating a neurosurgical procedure. With a bioassay method, peak and trough serum and cerebrospinal; fluid concentrations of moxalactam were determined during therapy. Mean peak and trough serum levels were 100.6 and 35.5 micrograms/ml, respectively. Corresponding mean peak and trough cerebrospinal fluid levels were 12.4 and 10.38 micrograms/ml. Cerebrospinal fluid levels of moxalactam exceeded the minimal bactericidal concentration for the infecting organism by more than 30-fold throughout therapy. No untoward effects of moxalactam were observed. Moxalactam may be a useful agent in the treatment of meningitis due to susceptible gram-negative bacilli.This publication has 11 references indexed in Scilit:
- Diffusion of a new beta-lactam (LY 127935) into cerebrospinal fluidAmerican Journal Of Medicine, 1980
- Comparison of moxalactam (LY127935) and cefotaxime against anaerobic bacteriaAntimicrobial Agents and Chemotherapy, 1980
- In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strainsAntimicrobial Agents and Chemotherapy, 1980
- Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycinAntimicrobial Agents and Chemotherapy, 1980
- Cefoxitin concentrations in the cerebrospinal fluids of patients with meningitisAntimicrobial Agents and Chemotherapy, 1980
- Moxalactam (6059-S), a Novel 1-Oxa-β-Lactam with an Expanded Antibacterial Spectrum: Laboratory EvaluationAntimicrobial Agents and Chemotherapy, 1980
- Failure of Cefamandole in Treatment of Meningitis Due to Haemophilus influenzae Type bThe Journal of Infectious Diseases, 1978
- Simple Method for Elimination of Aminoglycosides from Serum to Permit Bioassay of Other Antimicrobial AgentsAntimicrobial Agents and Chemotherapy, 1977
- Penetration of Cefamandole into Spinal FluidAntimicrobial Agents and Chemotherapy, 1977
- Gram-negative bacillary meningitisAmerican Journal Of Medicine, 1975