Copper-Zinc and Manganese Superoxide Dismutase Activities in Cardiac and Skeletal Muscles during Aging in Male Rats
- 31 December 1983
- journal article
- research article
- Published by S. Karger AG in Gerontology
- Vol. 30 (3), 153-158
- https://doi.org/10.1159/000212623
Abstract
The activities of total superoxide dismutase (SOD) and the manganese (Mn SOD) and copper-zinc (Cu-Zn SOD) forms were determined in the supernatant fraction of heart, liver and six skeletal muscles from rats during aging. Total SOD activity increased in most muscles between 3 and 23 months of age. There was no change in activity in liver between 3 and 19 months of age. The increase in total activity in heart was due to increased Mn SOD activity, whereas increases in skeletal muscles were due to Cu-Zn SOD or to both Cu-Zn and Mn SOD. The nutritional implications during aging are discussed.Keywords
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