Chronic lymphocytic leukemia: A monoclonal disease
- 1 September 1982
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 13 (2), 159-162
- https://doi.org/10.1002/ajh.2830130208
Abstract
A black woman with chronic lymphocytic leukemia (CLL) was found to have monoclonal B lymphocytes with one type of surface immunoglobulin and one variant of G6PD (glucose‐6‐phosphate dehydrogenase) (G6PD A). Erythrocytes and T cells contained both G6PD A and G6PD B and hence were of polyclonal origin. The CLL cells in this patient likely arose from a developmental stage later than the step of differentiation into T and B lymphocytes. Furthermore, her erythrocytes did not arise from a stem cell affected by the CLL process.Keywords
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