Effects of Antacid, Antipeptic and Anticholinergic Agents on the Development and Healing of Duodenal Ulcers in the Rat

Abstract

Early stages of the duodenal ulcer induced by acetic acid in rats were studied. The necrotized mucosa in the duodenum gradually progressed to a deep ulcer by the 5 postoperative days, then the ulcer reduced in size and depth considerably by the 10th day. Aluminum hydroxide, amylopectine sulfate and atropine sulfate, given for 5 days beginning immediately after the operation, inhibited the ulceration weakly but lessened the incidence of rats with deep ulcer. Aluminum hydroxide and amylopectine sulfate, given for 8 days beginning 1 day after the operation, significantly accelerated the healing of the duodenal ulcer, i.e., these agents diminished the ulcerated area and its depth. However, atropine sulfate diminished the depth of ulcer crater while the ulcerated area remained unchanged in comparison with that of control group.