Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug "para-parai mi," Phyllanthus niruri.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (9), 2531-2532
- https://doi.org/10.1248/cpb.37.2531
Abstract
Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.This publication has 5 references indexed in Scilit:
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