The Formation of Histamine in the Rat

Abstract

Factors affecting the determination of histidine decarboxylase activity in adult rat tissues have been studied. The optimal conditions vary from tissue to tissue, and the most potent sources of the enzyme are the pyloric part of the stomach, the liver and the duodenum, with less in the kidney. There is no relationship between the histidine decarboxylase activity of a rat tissue and the amount of histamine it contains.