N-demethylation and N-oxidation of imipramine by rat and pig liver microsomes
- 31 August 1971
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 20 (8), 1921-1931
- https://doi.org/10.1016/0006-2952(71)90391-1
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Hepatic and extrahepatic metabolism of the psychotropic drugs, chlorpromazine, imipramine, and imipramine-N-oxideNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1971
- Studies on the inhibitory effects of various substances on drug metabolism by liver microsomes: The effect of nicotinamide in altering the apparent mechanism of inhibitionBiochemical Pharmacology, 1970
- The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitroBiochemical Pharmacology, 1970
- Effect of storage of frozen liver microsomal preparations on the hydroxylation of testosterone and pentobarbital and the N-demethylation of ethylmorphineBiochemical Pharmacology, 1969
- Metabolic interconversions between imipramine, its N-oxide, and its desmethyl derivative in rat tissues in vitroBiochemical and Biophysical Research Communications, 1968
- Sex differences in the kinetic constants for the n-demethylation of ethylmorphine by rat liver microsomesBiochemical Pharmacology, 1968
- The stability of the drug metabolising enzymes of liver microsomal preparationsBiochemical Pharmacology, 1964
- Formation of an intermediate N-oxide in the oxidative demethylation of N,N-dimethylaniline catalyzed by liver microsomesBiochemical and Biophysical Research Communications, 1964
- Conversion of tranquilizers to antidepressants by removal of one N-methyl groupLife Sciences, 1963
- Über die Konstitutionsermittlung und Synthese eines Metaboliten von N‐(γ‐Dimethylaminopropyl)‐iminodibenzyl‐hydrochlorid (Tofranil®)Helvetica Chimica Acta, 1960