Pigmented villonodular synovitis: Monoclonality and metastasis—a case for neoplastic origin?
- 1 January 1995
- journal article
- case report
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 66 (1), 64-68
- https://doi.org/10.3109/17453679508994643
Abstract
We report a 48-year follow-up of a case of recurrent pigmented villonodular synovitis of the knee. Subcutaneous metastasis to the contralateral thigh was an unusual finding. Histology demonstrated fibroblastic and histiocytic proliferation, as well as increased mitotic activity in recurrent lesions. Cytogenetic analyses demonstrated monoclonality and chromosomal abnormalities. Our findings support a neoplastic origin of this lesion.Keywords
This publication has 7 references indexed in Scilit:
- Chromosome aberrations in tenosynovial giant cell tumors and nontumorous synovial tissueGenes, Chromosomes and Cancer, 1993
- Trisomy 7 in nonneoplastic cellsGenes, Chromosomes and Cancer, 1993
- Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: Confirmation of trisomy 7 in uncultured cellsGenes, Chromosomes and Cancer, 1992
- Multiple clonal chromosome abnormalities in Peyronie's diseaseCancer Genetics and Cytogenetics, 1991
- Cytogenetic evidence of clonality in a case of pigmented villonodular synovitisCancer, 1991
- Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomasHuman Genetics, 1988
- Use Of Genetic Markers To Study Cellular Origin And Development Of Tumors In Human FemalesAdvances in Cancer Research, 1972