Self-association of Cholesterol in Aqueous Solution
- 1 August 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (8), 2313-2316
- https://doi.org/10.1073/pnas.70.8.2313
Abstract
Cholesterol has a maximum solubility in aqueous solutions of 1.8 mug/ml or 4.7 muM. It undergoes a thermodynamically reversible self-association with a critical micelle concentration of 25 to 40 nM at 25 degrees . The cholesterol micelle is heterogeneous in size, probably rodlike in shape, and stabilized by an unusually high interaction energy between the aggregated monomers.Keywords
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