Comparative in vitro activity of IY146032 (daptomycin), a new lipopeptide antimicrobial
- 1 February 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 6 (1), 100-103
- https://doi.org/10.1007/bf02097211
Abstract
The in vitro activity of LY146032, a new cyclic lipopeptide antibiotic, was compared with those of vancomycin, teicoplanin, and either oxacillin or ampicillin by determining agar dilution MIC values for 304 clinical gram-positive isolates. LY146032 had superior in vitro activity against oxacillin-resistant staphylococci when compared to vancomycin or teicoplanin. Against oxacillin-sensitive staphylococci, group JK-diphtheroids, streptococci,Listeria monocytogenes andClostridium difficile, LY146032 was equally or less active than vancomycin, teicoplanin, or the penicillins tested. When tested by macrobroth dilution MIC/MBC., LY 146032 showed good bactericidal activity against all organisms with the exception ofClostridium difficile.This publication has 5 references indexed in Scilit:
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