THE INFLUENCE OF ANTIDIURETIC HORMONE ON PANCREATIC EXOCRINE SECRETION

Abstract

Intravenous injections of an ADH preparation into unaesthetized dogs resulted in reduced rates of pancreatic exocrine flow, provided that the doses were above 4.2 mU/kg dog. There was a direct relationship between the percentage inhibition of pancreatic flow and the log of the dose of ADH administered. Oxytocin had no such effect in doses up to 83 mU/kg dog. During ADH inhibition, sodium, potassium and bicarbonate concentrations in the juice remained unchanged but protein and amylase concentrations increased. Sodium thioglycollate, sodium hydroxide, and ultraviolet light, all of which destroy ADH, destroyed the pancreas-inhibiting factor. Intravenous injection of hypertonic sodium chloride and hypertonic glucose solutions also reduced the rate of pancreatic exocrine flow. It is suggested that ADH can cause the isosmotic reabsorption of electrolytes from pancreatic secretion by an action on the cells of the pancreatic ducts.