MULTI-CENTER DOUBLE-BLIND EFFICACY AND SAFETY STUDY COMPARING ALPRAZOLAM, DIAZEPAM AND PLACEBO IN CLINICALLY ANXIOUS PATIENTS

Abstract

Both alprazolam and diazepam were superior to placebo for the treatment of the clinical anxiety syndrome throughout a 4-wk double-blind multiclinic trial of 976 outpatients. At the 4th-wk evaluation of the 845 patients completing the study, the 326 patients receiving alprazolam showed significantly more improvement than the 344 patients receiving diazepam on all 4 anxiety rating scales utilized (Hamilton Anxiety Rating Scale, Physician''s Global Assessment, Patient''s Global Assessment and Target Symptoms).