MIF-Like Activity in Simian Virus 40-Transformed 3T3 Fibroblast Cultures
- 13 September 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4155), 955-957
- https://doi.org/10.1126/science.185.4155.955
Abstract
Simian virus 40-transformed fibroblasts (SV3T3), as compared with their untransformed counterparts (3T3), elaborate a macromolecular product that inhibits macrophage migration and causes macrophages to aggregate and lose one type of cell coat material. I'he SV3T3 cells also lack this surface material relative to 3T3 cells. There may be a relationz between migration inhibition factor (MIF), the cell coat, and cell migration.Keywords
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