ACCUMULATION OF TECHNETIUM-99M STANNOUS PYROPHOSPHATE IN CONTUSED MYOCARDIUM

Abstract

The uptake of 99mTc stannous pyrophosphate in contused myocardium was measured as a function of time from the insult. The free wall of the dog''s left ventricle was surgically exposed and struck with a spring-loaded paddle. Pyrophosphate was injected i.v. from 1 1/2 to 47 1/2 h after the injury. After 1/2 h of incubation the hearts were removed and the 99mTc content of contused and noncontused myocardium was measured. Pyrophosphate was concentrated in contused myocardium at all time periods tested. Contused-to-normal ratios for pyrophosphate uptake ranged from 8.1 (8 h) to 41.9 (48 h).